| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -LYRIC/AEG1 Rabbit pAb | BKM-00157 | 50 μL |
Product Information
Description | LYRIC rabbit polyclonal antibody |
Protein full name | Protein LYRIC |
Synonyms | 3D3/LYRIC, Metadherin, Mtdh, Lyric, Lysine-rich CEACAM1 co-isolated protein, Metastasis adhesion protein |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse LYRIC |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Nucleus, Cytoplasm, Cell Membrane |
Predicted MW. | 64 kDa |
Observed MW. | 75 kDa |
Uniprot ID | Q86UE4, Q80WJ7, Q9Z1W6 |
Applications
Applications | Species | Dilution | Positive Sample |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | heart, brain |
Background
LYRIC protein also known as astrocyte elevated gene-1 protein (AEG-1). It is involved in HIF-1alpha mediated angiogenesis. AEG-1 also interacts with SND1 and involved in RNA-induced silencing complex (RISC) and plays very important role in RISC and miRNA functions. AEG-1 induces an oncogene called Late SV40 factor (LSF/TFCP2) which is involved in thymidylate synthase (TS) induction and DNA biosynthesis synthesis. Late SV40 factor enhances angiogenesis by transcriptionally up-regulating matrix metalloproteinase-9 (MMP9). AEG-1 acts as an oncogene in melanoma, malignant glioma, breast cancer and hepatocellular carcinoma. It is highly expressed in these cancers and helps in progression and development of these cancers. It is induced by c-Myc oncogene and plays very important role in anchorage independent growth of cancer cells.
Images
 |
Western blot analysis of LYRIC (GB111005) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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