| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -AMPK gamma 1 Rabbit pAb | BKM-00231 | 50 μL |
Product Information
Description | AMPK gamma 1 rabbit polyclonal antibody |
Protein full name | 5'-AMP-activated protein kinase subunit gamma-1 |
Synonyms | AMPK gamma1, AMPK subunit gamma-1, AMPKg, Prkag1, Prkaac |
Immunogen | Recombinant protein corresponding to Mouse AMPK gamma 1 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 38 kDa |
Observed MW. | 38 kDa |
Uniprot ID | O54950, P80385 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | heart, brain, muscle |
Background
AMP/ATP-binding subunit of AMP-activated protein kinase, an energy sensor protein kinase that plays a key role in regulating cellular energy metabolism. In response to reduction of intracellular ATP levels, AMPK activates energy-producing pathways and inhibits energy-consuming processes: inhibits protein, carbohydrate and lipid biosynthesis, as well as cell growth and proliferation. AMPK acts via direct phosphorylation of metabolic enzymes, and by longer-term effects via phosphorylation of transcription regulators. Also acts as a regulator of cellular polarity by remodeling the actin cytoskeleton; probably by indirectly activating myosin. Gamma non-catalytic subunit mediates binding to AMP, ADP and ATP, leading to activate or inhibit AMPK: AMP-binding results in allosteric activation of alpha catalytic subunit both by inducing phosphorylation and preventing dephosphorylation of catalytic subunits.
Images
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Western blot analysis of AMPK-γ1 (GB111090) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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