| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -FCGRT/FCRN Rabbit pAb | BKM-01118 | 50 μL |
Product Information
Description | FCGRT/FCRN rabbit polyclonal antibody |
Protein full name | IgG receptor FcRn large subunit p51 |
Synonyms | FcRn, IgG Fc fragment receptor transporter alpha chain, Neonatal Fc receptor, Fcgrt |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse FCGRT |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 40 kDa |
Observed MW. | 40 kDa |
Uniprot ID | Q61559 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse | 1: 500-1: 1000 | liver, kidney, small intestine |
Background
FcRN present in the intestinal epithelium of neonatal mice and rats mediates the selective uptake of immunoglobulin G (IgG) in mothers' milk, thereby helping newborn animals to acquire passive immunity. FcRn (also designated FCGRT, Brambell receptor, FcRn å chain, IgG Gc receptor and neonatal Fc-receptor) is comprised of a heavy chain and ∫-2-Microglobulin. FcRn heavy chain shows approximately 35% amino acid identity to an MHC class I molecule. FcRN localizes in endosomes of vascular endothelial cells and selectively recycles IgG to the cell surface, thus protecting IgG from lysosomal catabolism. This protection mechanism is a major constituent for ensuring IgG are the longest lived of all plasma proteins.
Images
| Western blot analysis of FCGRT (GB112081) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
扫码关注 更多精彩
在线客服
