| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -Cytohesin 3 Rabbit pAb | BKM-01383 | 50 μL |
Product Information
Description | Cytohesin 3 rabbit polyclonal antibody |
Protein full name | Cytohesin-3 |
Synonyms | ARF nucleotide-binding site opener 3, Protein ARNO3, General receptor of phosphoinositides 1, Grp1, PH, SEC7 and coiled-coil domain-containing protein 3, CLM3, SEC7 homolog C, mSec7-3, Pscd3, Cyth3 |
Immunogen | Recombinant protein corresponding to Mouse Cytohesin 3 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 46 kDa |
Observed MW. | 46 kDa |
Uniprot ID | O43739, O08967 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 250-1: 500 | lung, testis |
Background
GRP1 (general receptor for phosphoinositides-1) contains a Pleckstrin homology (PH) domain as well as a Sec7 domain. The PH domain has high binding affinity for phosphatidylinositol 3,4,5-trisphosphate Ptdlns(3,4,5)P3), while the Sec7 homology domain is responsible for catalyzing guanine nucleotide exchange of ADP-ribosylation factor (ARF) proteins. GRP1 co-localizes with ARF6 and catalyzes GTP/GDP exchange on ARF6. It is known to interact with Ptdlns(3,4,5)P3 localized to the plasma membrane in vitro and may also be a Ptdlns(3,4,5)P3 receptor. Additionally, GRP1 may regulate protein sorting and membrane trafficking through interaction with the guanosine triphosphate ARF, and may control cell adhesion through interaction with integrins.
Images
 | Western blot analysis of GRP1 (GB112389) at dilution of 1: 250 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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