| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -Lamin A + Lamin C Rabbit pAb | BKM-01394 | 50 μL |
Product Information
Description | Lamin A + Lamin C rabbit polyclonal antibody |
Protein full name | Prelamin-A/C |
Synonyms | Lamin-A/C, Lmna, Lmn1, Cardiomyopathy dilated 1A (autosomal dominant), LGMD1B, LFP, LMNA, Renal carcinoma antigen NYREN32 |
Immunogen | Recombinant protein corresponding to Mouse Lamin A + Lamin C |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 74 kDa |
Observed MW. | 74 kDa |
Uniprot ID | P48678 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse | 1: 500-1: 1000 | liver, colon |
Background
The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome.
Images
 | Western blot analysis of LaminAC (GB112400) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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