| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -Alpha-synuclein Rabbit pAb | BKM-01810 | 100 μL |
Product Information
Description | Alpha-synuclein rabbit polyclonal |
Protein full name | Alpha-synuclein |
Synonyms | Non-A beta component of AD amyloid, Non-A4 component of amyloid precursor, NACP, Snca, Syn |
Immunogen | Recombinant protein corresponding to Mouse Alpha-synuclein |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | |
Predicted MW. | 14 kDa |
Observed MW. | 18 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | hippocampus |
IHC | Human, Mouse, Rat | 1: 1500-1: 3000 | cerebellum |
ICC | Human | 1: 800-1: 1600 | SH-SY5Y |
Background
Alpha-synuclein is a member of the synuclein family, which also includes beta- and gamma-synuclein. Synucleins are abundantly expressed in the brain and alpha- and beta-synuclein inhibit phospholipase D2 selectively. SNCA may serve to integrate presynaptic signaling and membrane trafficking. Defects in SNCA have been implicated in the pathogenesis of Parkinson disease. SNCA peptides are a major component of amyloid plaques in the brains of patients with Alzheimer's disease.
Images
| Western blot analysis of Snca (GB112945) at dilution of 1: 1000 Lane 1: Mouse hippocampus tissue lysate Lane 2: Rat hippocampus tissue lysate |
| Immunohistochemistry analysis of paraffin-embedded human oligodendrocytoma using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse brain using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded rat brain using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded mouse cerebellum using Snca (GB112945) at dilution of 1: 3000 |
| Immunohistochemistry analysis of paraffin-embedded rat cerebellum using Snca (GB112945) at dilution of 1: 3000 |
| IImmunocytochemistry analysis of 4% paraformaldehyde-fixed SH-SY5Y cells using Alpha-synuclein GB112945 at dilution of 1: 1400 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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