| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -ARFGAP1 Rabbit pAb | BKM-02541 | 100 μL |
Product Information
Description | ARFGAP1 rabbit polyclonal |
Protein full name | ADP-ribosylation factor GTPase-activating protein 1 |
Synonyms | ARF GAP 1, ARF1 GAP, ARF1GAP, ARFGAP1, HRIHFB2281, ARF1-directed GTPase-activating protein |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse ARFGAP1 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 45 kDa |
Observed MW. | 50 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | brain |
Background
Protein coats deform flat lipid membranes into buds and capture membrane proteins to form transport vesicles. The assembly-disassembly cycle of the COPI coat on Golgi membranes is coupled to the GTP-GDP cycle of the small G protein ARF1. ARFGAP1 contributes to vesicle budding by increasing the GTPase activity of ARF1, because it promotes hydrolysis of the ARF1-bound GTP and thus, is required for the dissociation of coat proteins from Golgi-derived membranes and vesicles, a prerequisite for vesicle's fusion with target compartment. for ARFGAP1 may has a role in regulating the GTPase activity and neuronal toxicity of LRRK2; reciprocally, LRRK2 phosphorylates ArfGAP1 and is required for ArfGAP1 neuronal toxicity.
Images
 | Western blot analysis of ARFGAP1 (GB113718) at dilution of 1: 1000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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