| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -ABCB11/BSEP Rabbit pAb | BKM-02722 | 50 μL |
Product Information
Description | ABCB11/BSEP rabbit polyclonal antibody |
Protein full name | Bile salt export pump |
Synonyms | ABC16, ABCB11, Bile salt export pump, BRIC2, BSEP, PFIC 2, PFIC2, PGY4, SPGP |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse ABCB11/BSEP |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Endosome, Cell membrane |
Uniprot ID | Q9QY30 |
Applications
Applications | Species | Dilution | Positive Sample |
IHC/IF | Mouse, Rat | 1: 300-1: 1000 | liver |
Background
The membrane-associated protein encoded by this gene is a member of the superfamily of ATP-binding cassette (ABC) transporters. ABC proteins transport various molecules across extra- and intra-cellular membranes. ABC genes are divided into seven distinct subfamilies (ABC1, MDR/TAP, MRP, ALD, OABP, GCN20, White). This protein is a member of the MDR/TAP subfamily. Members of the MDR/TAP subfamily are involved in multidrug resistance. The protein encoded by this gene is the major canalicular bile salt export pump in man. Mutations in this gene cause a form of progressive familial intrahepatic cholestases which are a group of inherited disorders with severe cholestatic liver disease from early infancy.
Images
| Immunohistochemistry of paraffin embedded mouse liver using ABCB11 (GB113909) at dilution of 1: 500 (400x lens) |
| Immunohistochemistry of paraffin embedded rat liver using ABCB11 (GB113909) at dilution of 1: 500 (400x lens) |
| Immunofluorescence of paraffin embedded embedded mouse liver using ABCB11 (GB113909) at dilution of 1: 300 (400x lens) |
| Immunofluorescence of paraffin embedded embedded rat liver using ABCB11 (GB113909) at dilution of 1: 300 (400x lens) |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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