Product Information

Applications

Background

IL-10 is a cytokine with multiple, pleiotropic, effects in immunoregulation and inflammation. It downregulates the expression of Th1 cytokines, MHC class II antigens, and co-stimulatory molecules on macrophages. It also enhances B cell survival, proliferation, and antibody production. IL-10 can block NF-κB activity, and is involved in the regulation of the JAK-STAT signaling pathway. IL-10 is capable of inhibiting synthesis of pro-inflammatory cytokines such as IFN-γ, IL-2, IL-3, TNFα and GM-CSF made by cells such as macrophages and Th1 T cells. It also displays a potent ability to suppress the antigen-presentation capacity of antigen presenting cells. IL-10 is linked to the myokines, as exercise provokes an increase in circulating levels of IL-1ra, IL-10, and sTNF-R, suggesting that physical exercise fosters an environment of anti-inflammatory cytokines.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse inflammatory lung using IL-10 (GB11534) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin-embedded rat inflammatory lung using IL-10 (GB11534) at dilution of 1: 500
	Immunohistochemistry analysis of paraffin-embedded rat inflammatory spleen using IL-10 (GB11534) at dilution of 1: 1000

Storage

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.