| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -BLNK Rabbit pAb | BKM-04424 | 50 μL |
Product Information
Description | BLNK rabbit polyclonal |
Protein full name | B-cell linker protein |
Synonyms | Blnk, AGM4, BASH, BLNK-S, LY57, SLP-65, SLP65, Bca, B-cell linker |
Immunogen | Recombinant protein corresponding to Mouse BLNK |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Membrane |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
IHC | Mouse, Rat | 1: 3000-1: 5000 | spleen |
IF | Mouse, Rat | 1: 1500-1: 2500 | spleen |
Background
The function of BLNK was first illustrated in BLNK deficient DT40 cells, a chicken B-cell line, which exhibited an abrogated intracellular calcium mobilisation response and impaired activation of MAP kinases p38, JNK, and to a lesser degree ERK upon B-cell receptor (BCR) activation as compared to wild type DT40 cells. In knockout mice, BLNK deficiency results in a partial block in B-cell development, and in humans BLNK deficiency results in a much more profound block in B-cell development. Linker or adaptor proteins provide mechanisms by which receptors can amplify and regulate downstream effector proteins. The B-cell linker protein is essential for normal B-cell development.
Images
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using BLNK (GB11734) at dilution of 1: 3000 |
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Immunohistochemistry analysis of paraffin-embedded mouse spleen using BLNK (GB11734) at dilution of 1: 3000 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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