| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -CrkL Rabbit pAb | BKM-04444 | 100 μL |
Product Information
Description | CrkL rabbit polyclonal antibody |
Protein full name | Crk-like protein |
Synonyms | Crkl, CRKL, CRK like proto-oncogene, Adaptor protein |
Immunogen | Recombinant protein corresponding to Mouse CrkL |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 34 kDa |
Observed MW. | 39 kDa |
Uniprot ID | P46109, P47941, Q5U2U2 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Human, Mouse, Rat | 1: 500-1: 1000 | brain |
Background
V-CRK avian sarcoma virus CT10-homolog-like contains one SH2 domain and two SH3 domains. Crk-like protein encoded by the CRKL gene, has been shown to activate the RAS and JUN kinase signaling pathways and transform fibroblasts in a RAS-dependent fashion. It is a substrate of the BCR-ABL tyrosine kinase and plays a role in fibroblast transformation by BCR-ABL. In addition, CRKL has oncogenic potential. CrkL together with Crk participates in the Reelin signaling cascade downstream of DAB1.
Images
 |
Western blot analysis of crkl (GB11756) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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