| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -ATG3 Rabbit pAb | BKM-04517 | 50 μL |
Product Information
Description | ATG3 rabbit polyclonal antibody |
Protein full name | Ubiquitin-like-conjugating enzyme ATG3 |
Synonyms | Autophagy-related protein 3, Protein PC3-96, APG3-like, hApg3, ATG3, APG3, APG3L |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse ATG3 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 36 kDa |
Observed MW. | 40 kDa |
Uniprot ID | Q9CPX6, Q6AZ50 |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | muscle |
Background
E2-like enzyme involved in autophagy and mitochondrial homeostasis. Catalyzes the conjugation of ATG8-like proteins (GABARAP, GABARAPL1, GABARAPL2 or MAP1LC3A) to phosphatidylethanolamine (PE). PE-conjugation to ATG8-like proteins is essential for autophagy. Preferred substrate is MAP1LC3A. Also acts as an autocatalytic E2-like enzyme, catalyzing the conjugation of ATG12 to itself, ATG12 conjugation to ATG3 playing a role in mitochondrial homeostasis but not in autophagy. ATG7 (E1-like enzyme) facilitates this reaction by forming an E1-E2 complex with ATG3.
Images
 |
Western blot analysis of ATG3 (GB11839) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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