| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -Von Hippel Lindau/VHL Rabbit pAb | BKM-04559 | 50 μL |
Product Information
Description | VHL rabbit polyclonal antibody |
Protein full name | von Hippel-Lindau disease tumor suppressor |
Synonyms | Vhl, VHL, HRCA1, RCA1, VHL1, Pvon Hippel-Lindau tumor suppressor |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse VHL |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. | 20 kDa |
Observed MW. | 20 kDa |
Uniprot ID |
Applications
Applications | Species | Dilution | Positive Tissue |
WB | Mouse, Rat | 1: 500-1: 1000 | kidney, brain |
Background
The von Hippel–Lindau tumor suppressor also known as pVHL is a protein encoded by the VHL gene. Von Hippel-Lindau syndrome (VHL) is a dominantly inherited familial cancer syndrome predisposing to a variety of malignant and benign tumors. A germline mutation of this gene is the basis of familial inheritance of VHL syndrome. The protein encoded by this gene is a component of the protein complex that includes elongin B, elongin C, and cullin-2, and possesses ubiquitin ligase E3 activity. This protein is involved in the ubiquitination and degradation of hypoxia-inducible-factor (HIF), which is a transcription factor that plays a central role in the regulation of gene expression by oxygen. RNA polymerase II subunit POLR2G/RPB7 is also reported to be a target of this protein. Alternatively spliced transcript variants encoding distinct isoforms have been observed.
Images
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Western blot analysis of VHL (GB11890) at dilution of 1: 500 |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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