Product Information

Applications

Background

As part of the Ragulator complex it is involved in amino acid sensing and activation of mTORC1, a signaling complex promoting cell growth in response to growth factors, energy levels, and amino acids. Activated by amino acids through a mechanism involving the lysosomal V-ATPase, the Ragulator functions as a guanine nucleotide exchange factor activating the small GTPases Rag. Activated Ragulator and Rag GTPases function as a scaffold recruiting mTORC1 to lysosomes where it is in turn activated. Adapter protein that enhances the efficiency of the MAP kinase cascade facilitating the activation of MAPK2.

Images

	Immunohistochemistry analysis of paraffin-embedded mouse brain using LAMTOR2 (GB11935) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded rat brain using LAMTOR2 (GB11935) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded mouse lung using LAMTOR2 (GB11935) at dilution of 1: 1000
	Immunohistochemistry analysis of paraffin-embedded rat lung using LAMTOR2 (GB11935) at dilution of 1: 1500
	Immunohistochemistry analysis of paraffin-embedded mouse stomach using LAMTOR2 (GB11935) at dilution of 1: 1500

Storage

NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.