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Anti -Phospho-GSK3 Alpha / Beta (Y279/Y216) Rabbit pAb
BKM-04870
百科盟

产品信息

产品名称 产品编号 规格
Anti -Phospho-GSK3 Alpha / Beta (Y279/Y216) Rabbit pAb BKM-04870 50 μL

产品简介

Product Information


Description

Phospho-GSK3 Alpha /Beta (Y279/Y216) rabbit polyclonal

Protein full name

Glycogen synthase kinase-3 alpha/beta

Synonyms

GSK3B(Phospho-Tyr279+Tyr216), GSK3B(Phospho-Y279/Y216),

 p-GSK-3 Beta(Tyr279+Tyr216),

p-GSK-3 beta(Y279/Y216), Glycogen

synthase kinase 3 beta, GSK 3 beta, p-GSK3β, p-GSK3α, p-GSK3α/β

Immunogen

KLH conjugated Synthetic phosphopeptide corresponding to Human GSK3 Alpha /Beta (Y279/Y216)

Isotype

IgG

Purity

Affinity purification

Predicted MW.

47/51 kDa

Observed MW.

47/51 kDa

Uniprot ID

Q9WV60, P18266



Applications


Applications

Species

Dilution

Positive Tissue

WB

Mouse, Rat

1:500-1:1000

heart, brain




Background



Glycogen synthase kinase 3 (GSK3) is a proline directed serine threonine kinase that was initially identified as a phosphorylating and inactivating glycogen synthase, a key enzyme in glycogen metabolism. Since then, it has been shown to be involved in the regulation of a diverse array of cellular functions, including protein synthesis, cell proliferation, cell differentiation, microtubule assembly/disassembly, and apoptosis. There exists two isoforms of GSK3, alpha and beta, which are strictly regulated via phosphorylation. Phosphorylation of GSK3 beta on Ser9 (Ser21 in GSK3 alpha) is the primary mechanism responsible for growth factor inhibition of this kinase.




Images



图片 2.png

Western blot analysis of GSK3 Alpha /Beta (Y279/Y216)  (GB13160-1) at dilution of 1: 1000.





Storage



Storage Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles.
Storage Buffer PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol.




NOTE:

1.This product is intended for research only.

2.This product is recommended to dilute with the Primary Antibody Dilution Buffer (G2025).


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