| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -Amyloid beta 40 Rabbit pAb | BKM-00327 | 100 μL |
Product Information
Protein full name | Amyloid-beta precursor protein |
Synonyms | ABPP, APP, N-APP, Soluble APP-alpha, S-APP-alpha, C99, APP-C99, Abeta42, Abeta40, Beta-APP40, C83, APP-C59, Amyloid intracellular domain 59, APP-C57, Gamma-CTF(50), C31, App, Aβ40, Aβ42, A beta 40，beta Amyloid 40 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Mouse Aβ40 |
Uniprot ID | P12023 |
Isotype | IgG |
Purity | Affinity purification |
Subcellular location | Cell Membrane, Cytoplasm |
Applications
IHC/IF | Mouse, Rat | 1: 400-1: 1000 | Alzheimer's brain |
Background
Most of autosomal dominant familial AD can be attributed to mutations in one of three genes: those encoding amyloid precursor protein (APP) and presenilins 1 and 2 Most mutations in the APP and presenilin genes increase the production of a small protein called Aβ42, which is the main component of senile plaques. Some of the mutations merely alter the ratio between Aβ42 and the other major forms—particularly Aβ40—without increasing Aβ42 levels.
Images
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IHC analysis of Aβ40 (GB111197). Sample: Mouse Alzheimer's brain (Paraffin), 4% PFA (G1101) 12-24h. Antigen retrieval: Citrate buffer (pH 6.0) (G1201),98℃,20 min. Blocking buffer: 3% BSA in PBS (GC305010), RT, 30min. Primary antibody: 1: 400, 4℃ overnight. Secondary antibody: HRP Goat Anti-Rabbit lgG (GB23303), 1: 200 RT 1h. |
 | IHC analysis of Aβ40 (GB111197). Sample: Mouse Alzheimer's brain (Paraffin), 4% PFA (G1101) 12-24h. Antigen retrieval: Citrate buffer (pH 6.0) (G1201),98℃,20 min. Blocking buffer: 3% BSA in PBS (GC305010), RT, 30min. Primary antibody: 1: 400, 4℃ overnight. Secondary antibody: HRP Goat Anti-Rabbit lgG (GB23303), 1: 200 RT 1h. |
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IHC analysis of Aβ40 (GB111197). Sample: Mouse Alzheimer's brain (Paraffin), 4% PFA (G1101) 12-24h. Antigen retrieval: Citrate buffer (pH 6.0) (G1201),98℃,20 min. Blocking buffer: 3% BSA in PBS (GC305010), RT, 30min. Primary antibody: 1: 1000, 4℃ overnight. Secondary antibody: HRP Goat Anti-Rabbit lgG (GB23303), 1: 200 RT 1h. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/ thaw cycles. |
| Storage Buffer | PBS with 0.02% sodium azide, 100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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