| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -Phospho-p70 S6 Kinase (T389) Rabbit pAb | BKM-02628 | 50 μL |
Product Information
Protein full name | Ribosomal protein S6 kinase beta-1 |
Synonyms | S6K-beta-1, p70 alpha, p70 ribosomal S6 kinase alpha, p70 S6 kinase alpha, p70 S6K 1, p70 S6K alpha, p70 S6KA, p70(S6K), p70(S6K) alpha, p70S6K, P70S6K1, PS6K, Ribosomal protein S6 kinase I, RPS6KB1, S6K, S6K1, STK14A |
Immunogen | KLH conjugated Synthetic phosphopeptide corresponding to Human p70S6K around the phosphorylation site of T389 |
Uniprot ID | P23443 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. / Observed MW. | 50-60 kDa / 65 kDa |
Applications
WB | Human, Mouse, Rat | 1: 500-1: 1000 | 293, NIH/3T3, PC-12 |
Background
RPS6KB1(Ribosomal protein S6 kinase beta-1) is also named as STK14A, p70 S6KA and belongs to the S6 kinase subfamily. RPS6KB1 is a major substrate of MTOR and acts as a crucial effector of MTOR signaling pathway. It plays a key role in cell growth and proliferation by regulating INS sensitivity, metabolism, protein synthesis, and cell cycle. RPS6KB1 may play an important role in the progression of HCC and could serve as a potential molecular target for HCC therapy . RPS6KB1 is a 70 kDa protein and has 5 isoforms with the calculated molecular mass of 51-59 kDa produced by alternative initiation.
Images
| WB analysis of Phospho-p70 S6 Kinase (T389)（GB113805） Sample:Protein treated by RIPA LysisBuffer (G2002). Blocking buffer:3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1:1000,4℃overnight. Secondary antibody:HRP Goat Anti-Rabbit lgG (GB23303), 1: 3000, RT, 1h. |
 | WB analysis of Phospho-p70 S6 Kinase (T389)（GB113805） Sample:Protein treated by RIPA LysisBuffer (G2002). Blocking buffer:3% Nonfat dry milk (GC310001) in TBST, RT, 1h. Primary antibody: 1:1000,4℃overnight. Secondary antibody:HRP Goat Anti-Rabbit lgG (GB23303), 1: 3000, RT, 1h. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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