| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti-Phospho-EGFR(Y1069) Rabbit pAb | BKM-04237 | 100 μL |
Product Information
Protein full name | Epidermal growth factor receptor |
Synonyms | EGFR, ERBB, ErbB1, HER1, mENA, Phospho-EGFR (Tyr1045), Phospho-EGFR (Tyr1069), PIG61, Proto oncogene c ErbB 1 |
Immunogen | KLH conjugated Synthetic phosphopeptide corresponding to Human EGFR(Y1069) |
Uniprot ID | P00533 |
Isotype | IgG |
Purity | Affinity purification |
Predicted MW. / Observed MW. | 134/45/77/69 kDa / 175 kDa |
Applications
WB | Human | 1: 300-1: 500 | A-431 |
Background
Receptor tyrosine kinase binding ligands of the EGF family and activating several signaling cascades to convert extracellular cues into appropriate cellular responses.
Known ligands include EGF, TGFA/TGF-alpha, AREG, epigen/EPGN, BTC/betacellulin, epiregulin/EREG and HBEGF/heparin-binding EGF.
Ligand binding triggers receptor homo- and/or heterodimerization and autophosphorylation on key cytoplasmic residues. The phosphorylated receptor recruits adapter proteins like GRB2 which in turn activates complex downstream signaling cascades. Activates at least 4 major downstream signaling cascades including the RAS-RAF-MEK-ERK, PI3 kinase-AKT, PLCgamma-PKC and STATs modules.
Images
| WB analysis of Phospho-EGFR(Y1069)(GB115662). |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.02%sodium azide,100 μg/ml BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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