| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Anti -CREBBP + KAT3B / p300 Mouse mAb | BKM-04936 | 50 μL |
Product Information
Gene Name | |
Protein Name | Histone acetyltransferase p300 |
Synonyms | p300 HAT, E1A-associated protein p300, RSTS2, KAT3B, p300, CBP |
Human Gene Id | 5133 |
Human Swiss Prot No | Q09472 |
Immunogen | Recombinant fragment within Human KAT3B/ p300. |
Specificity | This antibody detects endogenous levels of human KAT3B / p300 |
Source | Mouse/IgG1, Kappa |
Concentration | 1 mg/ml |
Purification | The antibody was affinity-purified from mouse ascites by affinity-chromatography using specific immunogen. |
Applications
Applications | Species | Dilution |
IHC | Human | 1:200-1:500 |
IF | Human | 1:200-1:500 |
Background
EP300 encodes the adenovirus E1A-associated cellular p300 transcriptional co-activator protein. p300 is related by sequence to CPB (CREB-binding protein [CREB: cyclic-AMP responsive element binding protein]), and like CPB can stimulate transcription through activation of CREB. This EP300 activity is specifically inhibited by the adenovirus oncoprotein E1A. EP300 has also been identified as a co-activator of HIF1A (hypoxia-inducible factor 1 alpha), and thus plays a role in the stimulation of hypoxia-induced genes such as VEGF.
Images
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Immunohistochemical analysis of paraffin-embedded Tonsil. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citric acid ,pH6.0 was used for antigen retrieval. |
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Immunohistochemical analysis of paraffin-embedded Tonsil. 1, Antibody was diluted at 1:200(4°,overnight). 2, Citric acid ,pH6.0 was used for antigen retrieval. |
Storage
| Storage | Store at -20 ℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | Liquid in PBS containing 50% glycerol, 0.5% BSA and 0.02% sodium azide. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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