| 产品名称 | 产品编号 | 规格 |
|---|---|---|
| Recombinant Anti-PD-L1 antibody (Mouse mAb) | BKM-05102 | 100 μL |
Product Information
Protein full name | Programmed cell death 1 ligand 1 |
Synonyms | CD274, B7-H, B7H1, PDL-1, PDCD1L1, PDCD1LG1, PDL1, CD274 molecule, Programmed cell death 1 ligand 1 |
Immunogen | KLH conjugated Synthetic peptide corresponding to Human PD-L1 |
Uniprot ID | Q9NZQ7 |
Isotype | IgG1 |
Purity | Affinity purification |
Predicted MW. / Observed MW. | 33 kDa / 40-55 kDa |
Applications
WB | Human, Mouse, Rat | 1: 500-1: 1000 | lung, THP-1, U-87MG |
Background
Plays a critical role in induction and maintenance of immune tolerance to self.As a ligand for the inhibitory receptor PDCD1/PD-1, modulates the activation threshold of T-cells and limits T-cell effector response.Through a yet unknown activating receptor, may costimulate T-cell subsets that predominantly produce interleukin-10 (IL10).Can also act as a transcription coactivator: in response to hypoxia, translocates into the nucleus via its interaction with phosphorylated STAT3 and promotes transcription of GSDMC, leading to pyroptosis.The PDCD1-mediated inhibitory pathway is exploited by tumors to attenuate anti-tumor immunity and escape destruction by the immune system, thereby facilitating tumor survival.The interaction with PDCD1/PD-1 inhibits cytotoxic T lymphocytes (CTLs) effector function.The blockage of the PDCD1-mediated pathway results in the reversal of the exhausted T-cell phenotype and the normalization of the anti-tumor response, providing a rationale for cancer immunotherapy .
Images
| WB analysis of PD-L1(GB15339). Sample: Protein treated by RIPA Lysis Buffer (G2002). |
Storage
| Storage | Store at -20℃ for one year. Avoid repeated freeze/thaw cycles. |
| Storage Buffer | PBS with 0.15% ProClin300, 100 μg/mL BSA and 50% glycerol. |
NOTE:
1.This product is intended for research only.
2.This product is recommended to dilute with the Primary Antibody Dilution Buffer （G2025）.
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